In Vitro and in Vivo Effects of Three Different Mitragyna Speciosa Korth Leaf Extracts on Phase Ii Drug...

In Vitro and in Vivo effectuate of Three assorted Mitragyna speciosa Korth roll Extracts on Phase II Drug Metabolizing EnzymesGlutathione Transferases (GSTs)Molecules 2010, 15, 432-441; doi:10.3390/molecules15010432 boom ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Article In Vitro and in Vivo Effects of Three Different Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing EnzymesGlutathione Transferases (GSTs) Juzaili Azizi 1, Sabariah Ismail 1,*, Mohd Nizam Mordi 1, Surash Ramanathan 1, Mohd Ikram Mohd express 2 and Sharif Mahsufi Mansor 1 1 2 Centre for Drug Research, Universiti Sains Malaysia, 11800 USM Penang, Malaysia School of chemic Sciences and Food Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia * reservoir to whom correspondence should be addressed; email: sabaris@usm.my; Tel.: +60 46533269; facsimile: +60 46568669. Received: 30 November 2009; in revised chassis: 2 January 2010 / Accep ted: 7 January 2010 / produce: 20 January 2010 rear: In the present study, we investigate the cause of three distinct Mitragyna speciosa picks, namely methanolic, aqueous and keep down alkaloid extracts, on glutathione transferase- limited exertion in male Sprague Dawley rat liver cytosol in vitro and in vivo.

In the in vitro study, the effect of Mitragyna speciosa extracts (0.01 to 750 µg/mL) against the specific action mechanism of glutathione transferases was examined in rat liver cytosolic fraction from untreated rats. Our selective information show concentration dependent banning of cytosolic GSTs when Mitragyna speciosa e xtract was added into the reply mixture. At! the highest concentration used, the methanolic extract showed the highest GSTs specific activity inhibition (61%), followed by aqueous (50%) and total alkaloid extract (43%), respectively. In in vivo study, three different dosages; 50, 100 and 200 mg/kg for methanolic and aqueous extracts and 5, 10 and 20 mg/kg for total alkaloid extract were given...If you want to get a enough essay, put in it on our website: BestEssayCheap.com

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